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Before Dispensing Tolvaptan Lupin
Pharmacists should only dispense Tolvaptan Lupin prescribed by certified nephrologists. Prescriber’s certification status can be verified at www.tolvaptanlupinverify.com
Initial Tolvaptan Lupin Order
- • Nephrologist provides patient with approved PBS authority script (or private script) for Tolvaptan Lupin.
- • Patient takes script to their nominated pharmacy.
- • Pharmacist verifies that the prescriber is certified by cross checking the Tolvaptan Lupin prescriber database.
- • If a prescriber is not certified the pharmacist should:
- 1. Contact the non-certified prescriber to remind them of the TGA requirements for Tolvaptan Lupin and check whether Tolvaptan Lupin should still be dispensed to the patient.
- 2. Contact Lupin AU Medical Information team on 03 9809 7900, Option 2. Lupin AU will then contact the prescriber for education and certification.
- • Contact your preferred wholesaler to order Tolvaptan Lupin.
- • The initial Tolvaptan Lupin order must only be given for 28 days of treatment per patient.
- • Pharmacist should notify the patient when their Tolvaptan Lupin has arrived at the pharmacy.
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Tolvaptan Lupin Dosing and Titration
Tolvaptan Lupin is to be administered twice daily in split dose regimens, with a:
- • higher dose to be taken in the morning, ie. at least 30 minutes before breakfast or the morning meal; and
- • second, lower dose taken 8 hours later (with or without food).
Tolvaptan Lupin should not be taken with grapefruit juice due to increase in peak tolvaptan concentration
Dose Titration Process
Dose titration has to be performed cautiously to ensure that high doses are not poorly tolerated through overly rapid up – titration:
- • Patients may be down- titrated to lower doses based on tolerability.
- • Patients should be maintained on the highest tolerable tolvaptan dose.
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How to Take Tolvaptan Lupin
Instructions for patients on how to take Tolvaptan Lupin
Swallow the tablets whole with a glass of water, without splitting, chewing or
crushing the tablets.
Take the first daily dose at least 30 minutes before eating.
Take the second daily dose approximately 8 hours after the first daily dose, with
or without food.
Take your medicine at about the same time each day.
Drink plenty of water.
Do not drink grapefruit juice while you are on treatment with Tolvaptan Lupin.
For more detailed information, please refer to the links below
About
Tolvaptan Lupin
Tolvaptan Lupin is a medicine used for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD). It works by blocking the effects of vasopressin which slows down the rate at which cyst grow.
Because of the way Tolvaptan Lupin works, the patient is likely to experience thirst, an increased amount of urine and/or increased frequency of urination, including at night. Encourage them to talk to their healthcare team to understand how to best manage these side effects.
Please note: Not actual pharmacist image
Key Guidance for patients taking Tolvaptan Lupin
Do’s 
•
DO drink plenty of water during the day, before bedtime and after you urinate at night.
•
DO complete your blood tests for liver function monthly for the first 18 months and then every 3 months thereafter.
•
DO carry the Wallet Card with you at all times.
•
DO take your medicine for as long as the doctor tells you.
Dont’s 
•
DO NOT drink grapefruit juice while you are on treatment with Tolvaptan Lupin.
•
DO NOT give your medicine to anyone else, even if they have the same condition as you.
•
DO NOT stop taking the medicine unless your doctor advises you to.
•
DO NOT change the dose without checking with your doctor.
Frequently Asked Questions
What to do if your patient missed their dose?
If a dose is missed, patients should take the dose as soon as they remember on the same day. If patients do not take their tablets on one day, they should take their normal dose on the next day.
Patients MUST NOT take a double dose to make up for forgotten individual doses.
How to Store Tolvaptan Lupin?
Keep Tolvaptan Lupin in a cool, dry place where the temperature stays below 25° C. Keep it where young children cannot reach it.
What to do if you take too much?
If the patient thinks that they have taken too much Tolvaptan Lupin, they must immediately telephone the Poisons Information Centre (telephone Australia 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital. They should do this even if there are no signs of discomfort or poisoning. They may need urgent medical attention.